{"id":116244,"date":"2026-04-26T20:48:31","date_gmt":"2026-04-26T23:48:31","guid":{"rendered":"https:\/\/ubirataonline.com.br\/nicholas-hornstein-anticipating-resistance-and-revolution-medicines-proactive-strategy-for-ras-therapy\/"},"modified":"2026-04-26T20:48:43","modified_gmt":"2026-04-26T23:48:43","slug":"nicholas-hornstein-anticipating-resistance-and-revolution-medicines-proactive-strategy-for-ras-therapy","status":"publish","type":"post","link":"https:\/\/ubirataonline.com.br\/en\/nicholas-hornstein-anticipating-resistance-and-revolution-medicines-proactive-strategy-for-ras-therapy\/","title":{"rendered":"Nicholas Hornstein: Anticipating Resistance and Revolution Medicines&#8217; Proactive Strategy for RAS Therapy"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div id=\"article-body\">\n<p><strong>Nicholas Hornstein<\/strong>, Assistant Professor at Northwell Health, shared a post on\u00a0<a href=\"https:\/\/www.linkedin.com\/posts\/nicholas-hornstein-5183182a_aacr26-ugcPost-7452725454580674560-mlb3?utm_source=share&amp;utm_medium=member_desktop&amp;rcm=ACoAAFgRKrMBa6rtYPNmJt6GVlrii_I6dIuH-rY\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a>:<\/p>\n<p>\u201cDrug development is supposed to be linear.<\/p>\n<p>Build the drug \u2013 use the drug \u2013 resistance shows up \u2013 then figure out what to do next.<\/p>\n<p>And not what <strong>Revolution Medicines<\/strong> is doing.<\/p>\n<p>At <strong>AACR26,<\/strong> they disclosed <strong>RM-055<\/strong>, which honestly, is a unique concept.<\/p>\n<p>Before <strong>DaraxONRASib\u00a0<\/strong>is even fully in the world, they\u2019re building around resistance.<\/p>\n<p><strong>How it works:<\/strong><\/p>\n<ul>\n<li>Most mutant <strong>RAS<\/strong> proteins are relatively resistant to GAP-mediated hydrolysis<\/li>\n<li>That helps keep RAS in the active state<\/li>\n<li>They\u2019ve found a way to enhance that hydrolysis with RM-055<\/li>\n<\/ul>\n<p><strong>RM-055 can:<\/strong><\/p>\n<ul>\n<li>restore hydrolysis in mutant RAS<\/li>\n<li>flatten daraxonrasib-resistant models<\/li>\n<li>generate activity even in RAS-amplified settings<\/li>\n<\/ul>\n<p>That\u2019s a very smart way to think about this space.<\/p>\n<p>Not just \u2018here\u2019s our inhibitor.\u2019<\/p>\n<p><strong>More like:<\/strong> we already know resistance to our drug is coming, so let\u2019s start building now.<\/p>\n<p>That\u2019s how we cure cancer, not more me-toos (if I hear about another new PD1 program, I\u2019m going to cry).\u201d<\/p>\n<\/p>\n<p><em>Other articles featuring\u00a0<a href=\"https:\/\/oncodaily.com\/tag\/nicholas-hornstein\">Nicholas Hornstein<\/a>\u00a0on OncoDaily.<\/em><\/p>\n<\/p><\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/oncodaily.com\/voices\/nicholas-hornstein-490268\">Source link <\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Nicholas Hornstein, Assistant Professor at Northwell Health, shared a post on\u00a0LinkedIn: \u201cDrug development is supposed to be linear. Build the drug \u2013 use the drug \u2013 resistance shows up \u2013 then figure out what to do next. And not what Revolution Medicines is doing. At AACR26, they disclosed RM-055, which honestly, is a unique concept. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":116245,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"googlesitekit_rrm_CAow2JLhCw:productID":"","_gspb_post_css":"","maa_idioma":"","maa_pais":"","footnotes":""},"categories":[2725],"tags":[31389,31388,31390,6708,31391,31392,20838,18430,12200,14367],"class_list":["post-116244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-europe","tag-anticipating","tag-hornstein","tag-medicines","tag-nicholas","tag-proactive","tag-ras","tag-resistance","tag-revolution","tag-strategy","tag-therapy"],"blocksy_meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Nicholas Hornstein: Anticipating Resistance and Revolution Medicines&#039; Proactive Strategy for RAS Therapy - Ubirat\u00e3 Online Not\u00edcias - A realidade ao seu alcance!<\/title>\n<meta name=\"description\" content=\"Nicholas Hornstein, Assistant Professor at Northwell Health, shared a post on\u00a0LinkedIn: \u201cDrug development is supposed to be linear. 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